First each of two mailing lists are expanded in separate sessions with different hosts. Then the message is sent to everyone that appeared on either list (but no duplicates) via a relay host.
Step 1 -- Expanding the First List
R: 220 MIT-AI.ARPA Simple Mail Transfer Service Ready
S: HELO SU-SCORE.ARPA
R: 250 MIT-AI.ARPA
S: EXPN Example-People
R: 250-<ABC@MIT-MC.ARPA>
R: 250-Fred Fonebone <Fonebone@USC-ISIQ.ARPA>
R: 250-Xenon Y. Zither <XYZ@MIT-AI.ARPA>
R: 250-Quincy Smith <@USC-ISIF.ARPA:Q-Smith@ISI-VAXA.ARPA>
R: 250-<joe@foo-unix.ARPA>
R: 250 <xyz@bar-unix.ARPA>
S: QUIT
R: 221 MIT-AI.ARPA Service closing transmission channel
Step 2 -- Expanding the Second List
R: 220 MIT-MC.ARPA Simple Mail Transfer Service Ready
S: HELO SU-SCORE.ARPA
R: 250 MIT-MC.ARPA
S: EXPN Interested-Parties
R: 250-Al Calico <ABC@MIT-MC.ARPA>
R: 250-<XYZ@MIT-AI.ARPA>
R: 250-Quincy Smith <@USC-ISIF.ARPA:Q-Smith@ISI-VAXA.ARPA>
R: 250-<fred@BBN-UNIX.ARPA>
R: 250 <xyz@bar-unix.ARPA>
S: QUIT
R: 221 MIT-MC.ARPA Service closing transmission channel
Step 3 -- Mailing to All via a Relay Host
R: 220 USC-ISIE.ARPA Simple Mail Transfer Service Ready
S: HELO SU-SCORE.ARPA
R: 250 USC-ISIE.ARPA
S: MAIL FROM:<Account.Person@SU-SCORE.ARPA>
R: 250 OK
S: RCPT TO:<@USC-ISIE.ARPA:ABC@MIT-MC.ARPA>
R: 250 OK
S: RCPT TO:<@USC-ISIE.ARPA:Fonebone@USC-ISIQA.ARPA>
R: 250 OK
S: RCPT TO:<@USC-ISIE.ARPA:XYZ@MIT-AI.ARPA>
R: 250 OK
S: RCPT
TO:<@USC-ISIE.ARPA,@USC-ISIF.ARPA:Q-Smith@ISI-VAXA.ARPA>
R: 250 OK
S: RCPT TO:<@USC-ISIE.ARPA:joe@FOO-UNIX.ARPA>
R: 250 OK
S: RCPT TO:<@USC-ISIE.ARPA:xyz@BAR-UNIX.ARPA>
R: 250 OK
S: RCPT TO:<@USC-ISIE.ARPA:fred@BBN-UNIX.ARPA>
R: 250 OK
S: DATA
R: 354 Start mail input; end with <CRLF>.<CRLF>
S: Blah blah blah...
S: ...etc. etc. etc.
S: .
R: 250 OK
S: QUIT
R: 221 USC-ISIE.ARPA Service closing transmission channel
Scenario 7