The server understands and is willing to comply with the client's request, via the Upgrade message header field (section 14.41), for a change in the application protocol being used on this connection. The server will switch protocols to those defined by the response's Upgrade header field immediately after the empty line which terminates the 101 response.
The protocol should only be switched when it is advantageous to do so. For example, switching to a newer version of HTTP is advantageous over older versions, and switching to a real-time, synchronous protocol may be advantageous when delivering resources that use such features.